The commonest site for mycetoma is the foot (79.2%), most of the lesions are seen on the dorsal aspect of the forefoot. Both feet are equally affected. The hand ranks as the second commonest site (6.6%), the right hand is more affected. This may imply a traumatic basis of the infection in this site.
In endemic areas, other parts of the body may be involved but less frequently and these include the knee, arm, leg, head and neck, thigh and the perineum. Rare sites such as the chest and abdominal walls, fascial bones, mandible, paranasal sinuses, eyelid, vulva, orbit, scrotum and surgical incisions may be affected.