Annual Reports:
Mycetoma Research Centre Annual Report gives an overview of the work and Achievements of the centre.
Published Books
Mycetoma Clinicopathological Monograph. Prof. Ahmed Hassan Fahal,MBBS, FRCS, FRCSI, FRCSG MS, MD, FRCP(London) Professor of Surgery, University of Khartoum
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José Antonio Serrano Ángel Horacio Sandoval Blaine L. Beaman Click to download pdf Actinomicetoma |
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Dr. WW van de de Sande
Department of Medical Microbiology and Infectious Diseases Erasmus Medical Center
Rotterdam University |
Contribution to Books, Guidelines & News Letters
1. Ottawa 2010, Assessment & Technology, Consensus Statement. Zubar Amin, David A. Cook, Rachel Ellaway, Ahmad Fahal, Roger Kneebone, Moira Maley, Doris Ostergaard, GomindaPonamperuma, Andy Wearn, Jack Boulet, AmitaiZiv, 2011
2. van de Sande WWJ, Fahal AH, de Hoog GS, Van Belkum A Madurella. In: Liu D, editor. Molecular detection of human fungal pathogens. Boca Raton: CRC Press, Taylor & Francis Group. 2011, pp. 117–128.
3. Fahal, AH Mycetoma in Richard, Guerrant, Walker, Peter, Tropical Infectious Diseases: Principles, Pathogens and Practice. Third edition, Elsevier Publisher, 2011, chapter 83, pp. 565-568
4. Fahal AH. Mycetoma in Williams, Bulstrode, O'Connell, Bailey and Love's Short Practice of Surgery 26E: 26th Edition, Oxford University Press, 2013, pp 64-68.
5. vanBelkum A, Fahal, AH, van de Sande WW. Mycetoma by madurella mycetomatis: A completely neglected medico-social dilemma. In Hot Topics in Infection and Immunity in Children IX. Springer Science & Business Media New York 2012
6. Fahal AH, Mycetoma: Clinico-pathological Monograph, University of Khartoum Press. 2006.
7. Fahal AH, Actinomycetoma in Africa: in Serrano JA, Sandoval AH, Beaman BL. Actinomicetoma, Merida, Venezuela, 2006.
8. Hassan MA, Fahal AH. Mycetoma: in Tropical Surgery, Kamil R, Lumbly J, Westminster Publication LTD, 2004.
9. Fahal AH. Educational Development Centres in the Sudan in Ahmed A. The role of Diaspora in technology transfer and achieving sustainable development in Sudan UNCESCO, 2008 PP 77-80
10. Karrar EZ, Fahal, AH, Axander ES, Surgical skills, Educational Development Centre University of Khartoum, 2001.
11. Fahal AH, Evidence Based Guidelines for the Management of Mycetoma Patients, 2001.
12. Fahal AH, Ahmed ME, Imbabi ARS, How to write a thesis, Educational Development Centre University of Khartoum, 2006.
13. Fahal AH, Mycetoma in Mora-Montes HM, Leila M. Lopes-Bezerra L (Editors).Current Progress in Medical Mycology. Springer Nature, 2017pp 355-380
DOI 10.1007/978-3-319-64113-3
The MRC had established a new Institutional Review Board (IRB), which consists of 12 members with vast experience in ethics, research and clinical practice and they are of medical, health and social backgrounds.
The IRB has a chair, two Co-chairs, and it consists of a medical microbiologist, biostatistician, public health/community medicine physician, ethicist, educationist, sociologist, one community representative, and a WHO technical officer. Additional experts are invited upon need.
The board term of office is three years, however, membership can be terminated if a member is transferred, resigned, showed repeated, unjustified absenteeism, have been accused of proved misconduct, or have passed away. The IRB has clear terms of references, bylaws, and standard operating procedures. The board has regular meetings to review the research proposal from the centre and elsewhere.
Research & Development
The MRC is currently conducting several research projects in collaboration with several national and international research institutes and centres and these are:
Eighty-four patients with confirmed eumycetoma due to Madurella mycetomatis were enrolled so far in this first-ever double-blind clinical trial on eumycetoma treatment. The trial is a randomised, double-blind phase II proof-of-concept superiority trial of fosravuconazole 200 mg or 300 mg weekly dose versus itraconazole 400 mg daily dose, all three arms in combination with surgery, in patients with eumycetoma in Sudan. It is sponsored by the Drugs for Neglected Diseases Initiative (DNDi), Geneva and Eisa Ltd., Japan Company.
Still there a massive knowledge in mycetoma epidemiology, disease distribution, and its incidence and prevalence. Presently MRC is conducting a collaborative research project with Brighton and Sussex Medical School, UK (BSMS) supported by the National Institute of Health Research, UK. The project is targeting three mycetoma endemic states; Gaziera, Sennar and White Nile states. They were selected due to their high endemicity based on the MRC records. The study objectives are to determine the prevalence of mycetoma in Sudan, determine the role of environmental risk factors in the disease occurrence, population at risk and the socioeconomic impact of the disease in the affected population. The project duration is three years.
Mycetoma is a unique neglected tropical disease caused by a substantial number of microorganisms of fungal or bacterial origins. Identification of the causative organism and the disease extension are the first steps in the management of the affected patients and for predicting disease treatment outcome and prognosis. This project is a joint PhD programme between the Mycetoma Research Center and Erasmus Medical Center, Department of Medical Microbiology and Infectious Disease. The project aims to validate the M. mycetomatis specific PCR in a daily clinical setting, and identification and characterisation of the second most common causative agents in Sudan, the development of a multiplex specific PCR for the most common causative agents of mycetoma in Sudan. Moreover, designing and validation of M. mycetomatis specific real-time PCR directly on grains to ensure rapid identification and reduction in diagnosis time.
Mycetoma is a distinctive neglected tropical disease caused by a significant number of microorganisms of fungal or bacterial origins. However, currently, the route of infection in mycetoma is unclear. The project aims to study the soil-borne or thorn-prick-mediated theory of infection in this infection as well as the environmental factors roles in the disease transmission.
The present project aims to determine the possible role of arthropod vectors in the transmission of eumycetoma in an endemic area in the poor savanna belt in Eastern Sennar locality, Sennar State, Sudan.
The project aims to establish a Protein Biobank at the MRC in collaboration with the Department of Biochemistry, Faculty of Medicine, University of Khartoum. The material will be available for future protein identification and rapid mycetoma test design.
The MRC is establishing a biobank for the available biological material at the Centre. The material includes culture isolates, tissues, grains, sera, blood, and tissue blocks. With this system, this material will be handy and available for future research and collaboration with other research institutes and centres.
This project is sponsored by the Ministry of Higher Education and Scientific Research in collaboration with the Institute of Endemic Diseases, University of Khartoum and EL Azhari University. Its main objective is to design a point of care diagnostic test for mycetoma.
This project aims to study in depth the immunopathology of mycetoma, and that is in collaboration with the Infection and Inflammation Centre, York University, UK.
In collaboration with Brighton and Sussex Medical School, UK (BSMS) supported by the National Institute of Health Research the MRC is conducting a research project on the genetics of mycetoma. The project is examining the genetic background of mycetoma patients in certain endemic areas in Sudan, with the objective to bridge the knowledge gap in the susceptibility and resistance to mycetoma.
As a joint PhD programme between the MRC and Brighton and Sussex Medical School, UK (BSMS) supported by the National Institute of Health Research, UK an in-depth study on the various social impact of mycetoma on patients, families, community, and health system is currently conducted in Eastern Sennar, Sennar State.
Training & Research Fellowships
The MRC offers training and research fellowships to distinguished researchers and clinicians. In 2018 the MRC has offered three scholarships to international visiting clinicians for training in various aspects of mycetoma, and these were:
Research scholarships
Four research scholarships were offered to
The MRC fellowship:
The Mycetoma Research Center is pleased to recieve application for training fellowship on